Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Claramine (TFA) | 3030428-57-7 | 95.0% | 703.02 | 25 MG
Claramine TFA is a steroidal polyamine. It can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and toxins derived from biological proteins.
- Steroidal polyamine
- Regulates the properties of lipid membranes
- Protects cells from various biological toxins
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride
REAGENT Trifluoroacetic anhydride
Medchemexpress LLC ACV Tripeptide TFA | 477.45 | 25 MG
ACV Tripeptide TFA is a tripeptide that serves as the initial dedicated intermediate in the biosynthetic pathway leading to penicillin and cephalosporin classes of β-lactam natural products in bacteria and fungi. It is nonribosomally synthesized by the ACV synthetase (ACVS) enzyme, encoded by the 11 kb *pchAB* gene, and can be used for the biosynthesis of β-lactam antibiotics. This tripeptide contains the unusual amino acid α-aminoadipic acid (α-AAA), along with L-cysteine and D-valine.
- Tripeptide
- Initial intermediate in β-lactam biosynthesis
- Synthesized by ACV synthetase (ACVS) enzyme
- Contains α-aminoadipic acid (α-AAA), L-cysteine, and D-valine
- Molecular weight: 477.45
- Formula: C16H26F3N3O8S
- Appearance: Solid
Medchemexpress LLC xStAx-VHLL TFA | 100.0% | 3231.89 | 5 MG
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. It inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL TFA can also inhibit the proliferation of colon cancer cells and demonstrates anti-tumor activity.
- Induces β-catenin degradation in a dose-dependent manner in colorectal cancer cells in vitro
- Inhibits cell proliferation in vitro
- Inhibits Wnt/β-catenin signaling in HEK293T cells in vitro
- Shows antitumor activity in a mouse intestinal tumor model in vivo
- Reduces tumor number and active β-catenin protein levels in APC min/+ mice in vivo
Medchemexpress LLC OS-2966 5mg | 5mg
OS-2966 is a humanized antibody expressed in CHO cells targeting Integrin b1/ITGB1/CD29 OS-2966 carries a huIgG1 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 5 kDa The isotype control for OS-2966 can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC Vu0364572 TFA | 1240514-89-9 | MFCD31618417 | 99.3% | 487.51 g/mol | C23H32F3N3O5 | 5 MG
VU0364572 TFA is the trifluoroacetate salt of a selective M1 muscarinic receptor agonist intended for use in in vitro and in vivo pharmacology research. It is supplied as a high-purity solid powder for laboratory research applications.
- High purity (99.3%) suitable for research use.
- Trifluoroacetate salt form to aid solubility and handling.
- Solid powder form for convenient weighing and formulation.
- Available in small pack sizes appropriate for discovery and preclinical studies.
- Recommended sealed storage away from moisture and light; follow solvent storage guidelines for long-term stability.